This grand round has already taken place.
In 2009, Dr. Toretsky and his team revealed the molecule called YK-4-279 that targets Ewing Sarcoma with an article in Nature Medicine. YK-4-279 has the potential to be a potent new strategy in the fight against not only Ewing Sarcoma, but also other cancers and diseases with similar characteristics. YK-4-279 is an inhibitor of EWS-FLI1 oncoprotein. Dissection of EWS-FLI1 function with YK-4-279 has revealed activity in splicing and possibly chromatin regulation.
Dates and Times
Start: 5/24/2018 12:00 PM
End: 5/24/2018 1:00 PM
1. Recognize EWS-FLI1 as a therapeutic target in Ewing Sarcoma
2. Understand the challenge of creating a drug to inhibit EWS-FLI1
3. Recognize EWS-FLI1 regulates mRNA splicing
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