Thursday, May 6, 2021 at 12:00 PM
This grand round has already taken place.
May 6th, 2021 1.00 AMA PRA Category 1 Credit Hours
Description
My research area is focused on investigating the mechanisms of early pancreatic neoplasia and progression toward pancreatic cancer. Research from my group has demonstrated that KLF5 is an important regulator of acinar-to-ductal metaplasia (ADM) and mPanIN formation. Its deletion abrogates the pro-oncogenic effects of KRAS activating mutations alone or in the context of acute injury. Importantly, we showed that depletion of KLF5 increases expression of N-Myc Downstream-Regulated Gene 2 (NDRG2), a known tumor suppressor, and additionally reduces activation of STAT3. Currently, my laboratory studies the mechanisms of injury in pancreas and the role of pancreatic environment in disease progression. Furthermore, we investigate the therapeutic potential of novel compounds in inhibiting the progression of pancreatic diseases.
Dates and Times
Start: 5/6/2021 12:00 PM
End: 5/6/2021 1:00 PM
Objectives
1. Learn the role of cellular transdifferentiation in developing pathologies of early pancreatic neoplasia.
2. Learn the role of Krüppel-like factor 5 (KLF5) and N-Myc Downstream-Regulated Gene 2 (NDRG2) in the regulation of acinar-to-ductal metaplasia and early pancreatic neoplasia.
3. Learn animal models to study pancreatitis and progression towards pancreatic cancer.
Speakers
Accreditation
The School of Medicine, State University of New York at Stony Brook, is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The School of Medicine, State University of New York at Stony Brook designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credit(s) ™. Physicians should only claim the credit commensurate with the extent of their participation in the activity.
Need help with this Grand Round Session?
Please contact the Grand Round coordinator listed below:
Nancy Strein
Department: Pathology
Phone: (631) 444-3000
Email: nancy.strein@stonybrookmedicine.edu