Thursday, June 4, 2026 at 12:00 PM
Online Streaming Available
June 4th, 2026 1.00 AMA PRA Category 1 Credit Hours
Description
This presentation will introduce spatial transcriptomic approaches for mapping the bone marrow microenvironment and revisit the historical concept of the erythroblastic island as the canonical niche for erythropoiesis. By comparing murine and human bone marrow architecture using an unbiased spatial transcriptomic approach, the talk will re-examine whether the classical macrophage-centered erythroblastic island model applies to human erythropoiesis and highlight distinct cellular interaction programs that support erythroid maturation in human bone marrow.
Dates and Times
Start: 6/4/2026 12:00 PM
End: 6/4/2026 1:00 PM
Objectives
1. The murine erythropoietic niche is organized as an erythroblastic island centered on a distinct C1q-expressing macrophage population.
2. The human erythropoietic niche does not require central macrophages, but instead relies on ICAM-4–mediated cell–cell interactions between erythroblasts.
3. In patients with myelodysplastic syndromes, anemia is associated with decreased ICAM-4 expression in the erythroblasts and reduced erythroblast–erythroblast interactions.
Grand Round Files
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Speakers
Location
Basic Sciences Tower Level 9, Rm 140
101 Nicolls Rd
Stony Brook , NY 11794
Accreditation
The School of Medicine, State University of New York at Stony Brook, is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The School of Medicine, State University of New York at Stony Brook designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits ™. Physicians should only claim the credit commensurate with the extent of their participation in the activity.
Need help with this Grand Round Session?
Please contact the Grand Round coordinator listed below:
Rachel Larin
Department: Pathology Department
Phone: (631) 444-2169
Email: rachel.larin@stonybrookmedicine.edu