In 2025, we migrated 107 chemistry analytes from Roche Cobas to Abbott Alinity instruments. We reviewed manufacturer-led calibration, precision, linearity and method correlation data, performed reference range studies, and consulted the pediatric CALIPER database. Parathyroid hormone, hs-cTnT vs. hs-cTnI, and CA 19-9 exhibited proportional bias between platforms. Our institution-specific iPTH reference interval differed from manufacturer suggestions. We invited our oncologists to provide names o...